We cannot exclude that the cln3 transcript variants expressed in the SB-MO–treated morphants and in the two generated CRISPR lines may conserve some residual function, as it was reported for the Cln3 murine models and the most common 1-kb deletion variant found in JNCL patients (6, 42). The gene discussed is CLN3; the disease is juvenile neuronal ceroid lipofuscinosis.