In summary, based on preliminary exploration of the molecular mechanism of NRlncRNA SNHG6, we hypothesize that SNHG6 could potentially activate the PI3K/AKT signaling through regulating AXL and may hinder the necroptosis process in osteosarcoma cells, ultimately leading to the enhancement of proliferation, migration, and invasion in osteosarcoma. This evidence concerns the gene AKT1 and osteosarcoma.