In agreement with the lipid accumulation data (Figure 3, B and C), shPCYT1B mice did to some extent show higher frequency of liver dysfunction (raised aspartate transaminase [AST], alanine transaminase [ALT], and alkaline phosphatase [ALP]), and this effect could be totally blocked by addition of PC (Supplemental Figure 6C). The gene discussed is GPT; the disease is Decreased liver function.