Surprisingly, although the number of tumor-infiltrating neutrophils was not decreased in Ctsg–/– mice (Figure 10, N and O and Supplemental Figure 9F), the levels of NETs induced by the drug combination were substantially reduced in syngeneic tumors in Ctsg–/– mice compared with the Ctsg+/+ littermates (Figure 10P and Supplemental Figure 9G). This evidence concerns the gene CTSG and neoplasm.