CXCL5 and neoplasm: Figure 9, J–O show that the knockdown of p65 resulted in decreased levels of CXCL5 mRNA and secreted proteins. ChIP-qPCR analyses showed that p65 bound to the promoter regions of CXCL5 in Pik3ca-E545K mutant CMT93 cells (Figure 9P). Together, the data suggest that Pik3ca mutation activates the NF-κB pathway to upregulate CXCL5 in mouse CRCs, thereby attracting more tumor-infiltrating neutrophils.