To investigate this hypothesis, inflammatory chemokine mRNA expression (Ccl2, Cxcl1, Cxcl9, and Cxcl10) was assessed in whole LNs from WT and MARCO–/– mice at time points (8, 12, and 16 hours after infection) prior to the dominant type I IFN response observed at 24 hours (Figure 5) (12). The gene discussed is CXCL9; the disease is infection.