Lyve1 signal was observed in both subcapsular and medullary sinus regions, supporting the annotation of both floor and MARCO+ LEC subsets in the scRNA-Seq data set from 8 hours after infection and consistent with previous reports supporting the specificity of Lyve1 expression for floor (low level) and MARCO+ (high level) LECs (15, 16, 40). The gene discussed is MARCO; the disease is infection.