We hypothesized that if LAP1 and LULL1 are the only or major activators of torsinA in hepatocytes, then depletion of both will phenocopy the marked hepatic steatosis and VLDL secretion defect in A-CKO mice with depletion of torsinA from hepatocytes. The gene discussed is TOR1AIP1; the disease is Hepatic steatosis.