Understanding the requirements for protein crystal formation during type 2 immunity, studying the mechanisms whereby protein crystals stimulate type 2 immunity and having the proper tools to be able to distinguish between the soluble and the crystalline state will help us to better understand if targeting CLCs in human asthma and chronic rhinosinusitis with nasal polyps (CRSwNPs) would be of value. Here, ABCB1 is linked to asthma.