This nanovector was successfully used todeliver the chemotherapeutic drug NVP-BEZ235 into the brain and targetthe PDGFRβ overexpressed on the endothelial cells of vessels.Furthermore, the anti-PDGFRβ nanovectors accumulated in thebrain at 2 and 4 h after systemic administration.175 Li et al.176 demonstrated thatmodification of NPs with the rabies virus glycoprotein peptide (RVG29)enabled effective transport across the BBB in cellular and animalmodels of Parkinson’s disease. Here, PDGFRB is linked to Parkinson disease.