Forinstance, transferrin (Tf) is ferritin that can cross the BBB by bindingto the transferrin receptor (TfR) on the surface of ECs and has beenwidely used in the modification of nanocarriers as brain-targetingligands.171 Kuo et al. developed solidlipid NPs grafted with Tf and folic acid (FA) to deliver genes (BV6and GDC0152) into the brain for the treatment of GBM multiform. Here, TFRC is linked to glioblastoma.