The expression of E3 Ub ligase WW domain-containing protein 1 (WWP1) and YTH domain family protein 1 (YTHDF1) was found to be downregulated in the serum of both LPS- and ATP-induced mouse macrophage models and in cecum ligation- and puncture-induced sepsis mouse models. The gene discussed is YTHDF1; the disease is Sepsis.