NLRP3 and mastitis: In mammary tissues of mastitis-affected cows and mammary tissues of mice injected with Streptococcus lactis, a notable reduction in the expression of cyclin-dependent kinase 5 (CDK5) regulatory subunit-associated protein 3 (CDK5RAP3) was observed, and such reduction led to the enhancement of NLRP3 and IL1β protein expression and aggravation of autophagy and apoptosis.