NLRP3 and mastitis: However, CDK5RAP3 overexpression in mouse mammary tissues promoted its specific binding to NLRP3 inflammasomes, inducing ubiquitination modification of NLRP3 inflammasomes, facilitating the inactivation of NLRP3 inflammasomes, downregulating the expression of proteins downstream of NLRP3 inflammasomes, and thus inhibiting inflammation and pyroptosis in mastitis cells [42].