IL1A and liver disorder: Second, the relative abundance of these gut microbiota and gut metabolites, as well as the levels of IL-1a, TBA, and AST, were positively correlated with the transcription and translation of liver genes related to liver diseases and immunity (Fig. 7B; Fig. S1A) but negatively correlated with the transcription and translation of liver genes related to the glutathione metabolism pathway (Fig. 7C).