APOA5 and obesity due to melanocortin 4 receptor deficiency: MetS is a multifactorial disorder which may be influenced by genetic polymorphisms involved in the regulation of the obesity process, blood pressure, blood sugar levels, and lipid metabolism,30, 31 as evidenced by studies on protein‐coding genes nitric oxide synthase (NOS4) cluster of differentiation 36 (CD36), BUD13 Homolog (BUD13), ZPR1 Zinc Finger (ZPR1), and apolipoprotein A5 (APOA5) SNPs in the Iranian population.