The locus of the CDKN2A/B on chromosome 9p21 has been widely investigated and showed an association with a higher incidence of coronary artery calcium, ischemic stroke, obesity, T2DM, cardiomyopathy, myocardial infarction, coronary heart disease, and low HDL–cholesterol levels.32, 33, 34, 35, 36, 37. Here, CDKN2A is linked to ischemic stroke.