Several studies illustrated that IKAROS Family Zinc Finger 3 (IKZF3), long non‐coding RNAs cyclin‐dependent kinase inhibitor 2B (lncRNA CDKN2B‐AS1), and microRNA lethal 7‐a2 (let7‐a‐2) are involved in lipid metabolism disorders, type 2 diabetes mellitus, diabetic neuropathy, inflammation, cerebral and cardiovascular diseases, and atherosclerosis disorders through regulating numerous pathways comprising B lymphocyte proliferation and differentiation and lipid (especially TG and cholesterol) metabolism.16, 17, 18, 19. The gene discussed is IKZF3; the disease is diabetes mellitus.