CDKN2A and obesity due to melanocortin 4 receptor deficiency: The locus of the CDKN2A/B on chromosome 9p21 has been widely investigated and showed an association with a higher incidence of coronary artery calcium, ischemic stroke, obesity, T2DM, cardiomyopathy, myocardial infarction, coronary heart disease, and low HDL–cholesterol levels.32, 33, 34, 35, 36, 37