In a rodent stroke model, inhibition of TMEM16A with 2-(4-chloro-2-methylphenoxy)-N-[(2-methoxyphenyl)methylideneamino]-acetamide (Ani9) protected from microvascular ischaemic damage, dampened the rise in pericyte [Ca2+]i and capillary constriction, collectively improving cerebrovascular reperfusion in vivo[8▪▪]. The gene discussed is ANO1; the disease is Stroke.