found that the expression level of circulating EVs in septic patients was higher than that in healthy controls, and it inhibited T cell function in a concentration-dependent manner, which was represented by significantly reduced expression of CD69, up-regulated expression of PD-1 and increased proportion of Treg, which may be one of the mechanisms leading to immunosuppression of sepsis (119). The gene discussed is PDCD1; the disease is Sepsis.