CD274 and Sepsis: Different from those studies mentioned above, this review explores the role of PD-L1 in immunostimulatory and anti-inflammatory pathways, elucidates the intricate relationship between PD-L1 and the pathogenesis, development, and prognosis of sepsis, and summarizes current therapeutic approaches to PD-L1 in the treatment and prognosis of sepsis in preclinical and clinical studies, especially with a particular focus on PD-L1 expressed on neutrophils.