SFTPB and newborn respiratory distress syndrome: Furthermore, analysis of haplotypes encompassing rs1136451, rs4253527 (SFTPA2), -18 A>C (5’UTR), rs1130866 (+1580 C>T, Thr131Ile) (SFTPB, encoding a hydrophobic lung surfactant component, SP-B), rs721917 and rs17885900 (SFTPD) led to the conclusion that ACACCA and ACACCG patterns may increase RDS risk in preterms while ACACTG seems to be protective (142).