Both collectin-10 and collectin-11 are considered to be essential for fetal development: a variety of mutations of COLEC10, COLEC11 and MASP1/3 genes (the last one encodes MBL-associated serine proteases-1, -3 and non-enzymatic MAp-44, forming complexes with MBL, CL-10, CL-11 and ficolins) were reported in patients diagnosed with Malpuech, Michels, Mingarelli and Carnevale (3MC) syndrome, with craniofacial, renal or genital abnormalities, growth and intellectual disability [reviewed in (22)]. This evidence concerns the gene MBL2 and Intellectual disability.