High concentrations of pro-angiogenic factors, such as VEGF, angiopoietin 2 (ANG2), and platelet-derived growth factor (PDGF), are present in the TME (15) of various cancers, such as non-small cell lung cancer, gastric cancer, colorectal cancer, and glioma (16–20). The gene discussed is ANGPT2; the disease is colorectal cancer.