PDK2 and Insulin resistance: reported that either PDK2/PDK4 gene combined deletion or inhibition of PDK2/PDK4 by small-molecule inhibitors suppresses the inflammatory response of macrophages after inflammatory stimulation (LPS and IFN-γ), downregulates the expression of M1 macrophage markers, affects bactericidal activity, adhesion, and migration of macrophages, alleviates insulin resistance induced by obesity, and improves adipose tissue inflammation (86).