reported that either PDK2/PDK4 gene combined deletion or inhibition of PDK2/PDK4 by small-molecule inhibitors suppresses the inflammatory response of macrophages after inflammatory stimulation (LPS and IFN-γ), downregulates the expression of M1 macrophage markers, affects bactericidal activity, adhesion, and migration of macrophages, alleviates insulin resistance induced by obesity, and improves adipose tissue inflammation (86). The gene discussed is PDK4; the disease is obesity due to melanocortin 4 receptor deficiency.