TSPAN2 and Herpesviridae infectious disease: Cell-mediated responses also likely play a major role in herpesvirus infections, as we observed upregulation of both TSPAN2, a transmembrane protein expressed in neutrophils that modulates the inflammatory response, cell migration, and differentiation (88), and VNN3, an ectoenzyme secreted by neutrophils that is involved in oxidative stress and inflammation (89, 90).