However, the rapid induction of KCNB1 in response to acute stressors participate in the synaptic enhancement of the LHb, which is critical for behavioral deficits observed in depression animal models as well as patients (Sartorius et al., 2010; Li et al., 2011; Yang et al., 2018b). This evidence concerns the gene KCNB1 and depressive symptom measurement.