HOXC6 and cancer: In the Shanghai Cancer Center cohort (n = 300; low HOXC6 expression: n = 216; high HOXC6 expression: n = 84), high HOXC6 expression was significantly associated with an age of ≤54, right-sided colon cancer, poor differentiation, positive surgical margins, nerve invasion, the presence of one or more cancer nodules, and severe pathological stage (Supplementary Table 8).