Daesiho-Tang (DSHT) is an anti-obesity herbal formulation, and Ahtesham Hussain et al. found that DSHT could alter the composition of gut microbiota, regulate the expression of genes related to adiponectin and resistin in adipose tissue, and exhibit anti-diabetic effects in animals fed with HFD by lowering fasting blood glucose levels (219). The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.