It also phosphorylates SREBP-1c at Ser372, which inhibits proteolytic maturation, nuclear translocation of SREBP-1c and the expression of downstream fatty acid synthase gene, thus increasing fatty acid β-oxidation and reducing de novo synthesis of TG (25) to prevent hepatocyte steatosis by reducing the accumulation of TG in HepG2 cells (26). Here, SREBF1 is linked to steatosis.