utilizing flow cytometry have used different CAF markers (SMA, CD29, FAP, FSP1, PDGFRβ, CAV1) profiling them into four different CAF subtypes (CAF-S1 to CAF-S4) across breast and ovarian cancers (CAF-S1: CD29Med FAPHi FSP1Low-Hi αSMAHi PDGFRβMed-Hi CAV1Low; CAF-S2: CD29Low FAPNeg FSP1Neg-Low αSMANeg PDGFRβNeg CAV1Neg; CAF-S3: CD29Med FAPNeg FSP1Med-Hi αSMANeg-Low PDGFRβMed CAV1Neg-Low; CAF-S4: CD29Hi FAPNeg FSP1Low-Med αSMAHi PDGFRβLow-Med CAV1Neg-Low) (28, 47). This evidence concerns the gene SMN1 and ovarian carcinoma.