VEGFA and tongue squamous cell carcinoma: In contrast, a more recent meta-analysis of several different biomarkers in oral tongue SCC found that increased VEGF-C expression was actually associated with improved survival and VEGF-A and VEGF-C expression together were not significantly prognostic; however, when the single VEGF-C study was excluded from the meta-analysis VEGF-A expression alone demonstrated strong prognostic significance in OS in patients with tongue SCC (28).