NT-proBNP, N-terminal pro-B-type natriuretic peptide; LVEF, left ventricular ejection fraction; MR, mitral regurgitation; HBA1c, hemoglobin A1c; LDL, low-density lipoprotein; IQR, interquartile range; HFrEF, heart failure with reduced ejection fraction. Here, NPPB is linked to mitral valve insufficiency.