APOE and Alzheimer disease: Continuing with examples from AD, the APP A673T variant suppresses amyloid beta production (Di Fede et al., 2009; Jonsson et al., 2012), while APOE R136S (Christchurch) and RELN H3447R resist downstream pathologic tau accumulation (Arboleda-Velasquez et al., 2019; Lopera et al., 2023).