Although, given the high prevalence of aggressive BC reported in young Brazilian women, GES et al. highlighted in a cohort of black women of African slaves descent, 24.1% (28/116) carrying pathogenic variants in ATM, BARD1, BRCA1, BRCA2, BRIP1, FAM174A, FANCM, PALB2, and TP53. The gene discussed is TP53; the disease is breast cancer.