Endogenous CS can be divided into ACTH dependent forms such as ectopic CS and pituitary ACTH-secreting tumours or ACTH independent forms including adrenocortical tumours (adenoma or carcinoma) and primary adrenocortical hyperplasia such as primary pigmented nodular adrenocortical disease (PNAD), primary bilateral adrenal macronodular hyperplasia (PBAMH) and McCune-Albright syndrome. The gene discussed is POMC; the disease is carcinoma.