Disrupted-in-schizophrenia-1 (DISC1) was first identified at the breakpoint of a balanced chromosomal translocation (1; 11) (q42.1; q14.3) in a Scottish family with a history of schizophrenia and related psychiatric disorders (Millar et al., 2000; Millar et al., 2001). Here, DISC1 is linked to schizophrenia.