TGFB3 and intervertebral disk degenerative disorder: In vivo models of acupuncture in rats show that IDD is alleviated by the intravertebral disc injection of circ_0022382. Mechanistically, the development of IDD generated by intermittent mechanical tension is effectively blocked by the circ_0022382-miR-4726-5p-TGF-β3 axis by inhibiting the development of cartilage endplate cell degeneration.