CircRNAs also promote or inhibit disc degeneration by modulating several pathological processes, including proliferation, apoptosis, phagocytosis, and senescence in the NP and chondrocytes and the expression of key components of the ECM, anabolic regulators of the ECM such as MMP and ADAMTS, and inflammatory cytokines such as IL-1. This evidence concerns the gene IL1B and intervertebral disk degenerative disorder.