GO analysis indicated that these genes were mainly related to T cell and B cell activation, suggesting that MTB could indirectly affect other immune cells by targeting NK cells (Figure 7b), consistent with the result from a previous study.[22] Besides, we find that some DEGs (e.g., KLRC1 and KLRC2) were enriched into the pathways of NK cell cytotoxicity and leukocyte migration (Figure 7c), revealing the diverse and important roles of NK cells in TB. This evidence concerns the gene KLRC2 and tuberculosis.