These results hint at the fact that functional alternation of B cell subtypes could be related to their abundance rather than their transcriptomic characteristics, which was also observed in the nasopharyngeal carcinoma environment.[20] As shown in the gene regulatory network, XBP1 exhibited a more generic regulatory relationship than other genes and appeared to be a “hub gene.” XBP1 is involved in the expression of 123 genes (Figure 6e). The gene discussed is XBP1; the disease is nasopharyngeal carcinoma.