In ECM‐treated mice, we saw enrichment of multiple immune‐related gene sets in B6 mice, including IL‐4 signaling (FDR<0.001) (associated with M2 macrophages and a Th2 polarized immune response), neutrophil degranulation (FDR < 0.001) (associated with early granulocytic infiltration to degrade debris and fight infection), innate response (which includes granulocytes as well as macrophages), and M2 macrophages (which correlates with the IL‐4 signaling enrichment, Figure 2f). This evidence concerns the gene IL4 and infection.