Changes in insulin concentrations reflect those of BMI with robust decreases from 16.5 (13.3–27.5) mU/L to 8.0 (7.0–10.8) mU/L for the type 2 diabetes group and from 16.5 (9.0–26.5) mU/L to 10.0 (7.8–14.0) mU/L for the nondiabetic group. The gene discussed is INS; the disease is type 2 diabetes mellitus.