Figure 1B depicts results from regression modelling, together with the effects of various adjustments (sex + age, sex + age + BMI, sex + age + insulin, sex + age + glucose, and sex + age + history of type 2 diabetes), on how BMI, insulin, glucose, and HbA1c changed between the 6-month time point after the RYGB surgery and the preoperative time point. The gene discussed is INS; the disease is type 2 diabetes mellitus.