Schematic diagram (Fig. 7) demonstrating the inhibitory effect of circIGF1R on NSCLC migration and invasion via miR-1270/VANGL2/WNT pathway and that paclitaxel inhibits NSCLC invasion and migration by increasing circIGF1R biogenesis via RBFOX3. Here, RBFOX3 is linked to non-small cell lung carcinoma.