In conclusion, circIGF1R acts a tumor suppressor in NSCLC by inhibiting the Wnt pathway through the VANGL2/miR-1270 axis, RBFOX3 promotes circIGF1R biogenesis by binding to IGF1R pre-mRNA, and is induced by paclitaxel to inhibit the migration and invasion of NSCLC cells. Here, VANGL2 is linked to non-small cell lung carcinoma.