Quantitative immunoblotting showed highly variable levels of total LRRK2 which were not significantly different amongst control, R1441G-LRRK2 PD, R1441G-LRRK2 NMC, G2019S-LRRK2 PD, G2019S-LRRK2 NMC and idiopathic PD LCLs, whilst the levels of total Rab10 were more similar (Fig. 5a, b). The gene discussed is RAB10; the disease is Parkinson disease.