C/C splitting in R1441G-LRRK2 PD and G2019S-LRRK2 PD strongly predicted a PD diagnosis with a ROC area under the curve c-statistic of 1.0, with a lower value obtained for R1441G-LRRK2 and G2019S-LRRK2 NMCs (Supplementary Fig. 7). The gene discussed is LRRK2; the disease is Parkinson disease.