LRRK2 and Parkinson disease: Such lack of LLOMe-mediated potentiation of pT73-Rab10 levels marginally correlated with high basal levels of pT73-Rab10 in the absence of LLOMe treatment (Fig. 3d), and further work is required to determine whether these idiopathic PD patient-derived cells already harbor lysosomal damage and thus display maximal LRRK2 kinase activity.