IL18 and Sepsis: Second, we found that pairwise cytokine perturbations counteracted most of the gene expression changes due to CLP sepsis, with total overlaps in DEGs ranging from 31.9% (2,267/7,106 genes) for anti-TNF + Il1b−/−, 45.6% (3,242/7,106 genes) for anti-TNF + Il18−/−, to 63.3% (4,497/7,106 genes) for anti-TNF + Ifng−/− (Fig. 4c and Supplementary Table 5c).