We demonstrated for the first time that Fgl2−/− mice have more DNAM-1+ NK cells and higher expression of NKG2D+ and NKG2A+ markers (Fig. 6) and that these DNAM-1+ NK cells are found at higher frequencies in both ovarian (ID8-p53−/−Brca2−/−) and melanoma (B16F10) tumours. Here, CD226 is linked to neoplasm.