Depleting CD4+ and CD8+ T cells in FGL2WT versus Fgl2−/− B16F10 tumour-bearing mice showed the dependence on both CD4 and CD8 T cells for prolonged survival in Fgl2−/− mice, which further supports the involvement of the adaptive immune system and importance of a strong antigenic response in the role of FGL2-mediated tumour progression. Here, CD4 is linked to neoplasm.