The drug-discovery approach taken here, and the small molecule(s) it has identified, may for the first time provide an effective preventative approach to directly foil the devastating effects of inheriting APOEε4 alleles, not only for development of Alzheimer’s disease but also with respect to the many other maladies associated with the inheritance of the APOE4 allele(s)1,28,29. The gene discussed is APOE; the disease is Alzheimer disease.