Similarly, we provided evidence of an ApoE4-related increase in aggregates in a human cell culture model, which mirrored a marked diminution in transcription of three lysosomal autophagy-dependent transcription factor-EB (TFEB)-regulated mRNA transcripts (SQSTM1, LAMP2, and MAP1LC3B) in brain tissues from AD patient carriers of APOEε4,4 compared to those from AD APOEε3,ε3 carriers4. This evidence concerns the gene LAMP2 and Alzheimer disease.