Our nematode model recapitulates the AD-like scenario in that co-expression of human ApoE4 and Aβ1–42 in C. elegans (ApoE4; Aβ::mcherry worms) results in a 45% increase in Aβ::mcherry aggregation relative to ApoE3; Aβ::mcherry worms (Fig. 5b). Here, APOE is linked to Alzheimer disease.