APOE and Alzheimer disease: Similarly, we provided evidence of an ApoE4-related increase in aggregates in a human cell culture model, which mirrored a marked diminution in transcription of three lysosomal autophagy-dependent transcription factor-EB (TFEB)-regulated mRNA transcripts (SQSTM1, LAMP2, and MAP1LC3B) in brain tissues from AD patient carriers of APOEε4,4 compared to those from AD APOEε3,ε3 carriers4.