MFRP and Abnormal retinal morphology: Next, we sought to test the therapeutic utility of in vivo PE delivery via PE-eVLPs by correcting a mutation causing retinal disease in rd6 mice, a model of autosomal recessive retinal degeneration caused by a 4-bp deletion in the splice donor of the membrane-type frizzled-related protein (Mfrp) gene71 (Fig. 5a).