Considering the visualization of coverage indicating enrichment of PKM2 in MS brains (Supplementary Fig. 8b), we decided to pursue this in our more controlled mouse model and found that Pkm2 was clearly enriched in EAE (Supplementary Fig. 8d) samples, confirming changes of an hnRNP A1-regulated splicing event in disease. Here, PKM is linked to myeloid sarcoma.