Active induction of EAE in C57Bl/6 mice with myelin oligodendrocyte glycoprotein peptide (MOG33-55) leads to the recapitulation of features of MS, including extensive neurodegeneration and neuronal hnRNP A1 mislocalization36,37,45,46 (Fig. 2a), which primarily manifest in the spinal cord. This evidence concerns the gene OMG and myeloid sarcoma.