Active induction of EAE in C57Bl/6 mice with myelin oligodendrocyte glycoprotein peptide (MOG33-55) leads to the recapitulation of features of MS, including extensive neurodegeneration and neuronal hnRNP A1 mislocalization36,37,45,46 (Fig. 2a), which primarily manifest in the spinal cord. The gene discussed is MOG; the disease is myeloid sarcoma.