We provide robust evidence of five high-risk and causal (LRRK2 p.G2019S, GBA1 p.N409S, p.T408M, p.E365K, PRKN p.R275W) and five variants potentially strongly involved in PD disease development (LRRK2 p.R1441H, p.L1795F, GBA1 p.R502C, p.R296Q, p.D179H). Here, PRKN is linked to Parkinson disease.