PRKN and Parkinson disease: Most of our statistical models used here are based on additive effects and since only summary-level data was available from 23andMe, we cannot accurately report results on autosomal recessive genes such as PRKN and PINK1. To highlight this further the PRKN p.R275W (rs34424986) variant is known to increase the risk for PD in a homozygous or compound heterozygous state39.