In particular, ref. 130 demonstrated that NME2 plays a vital role in maintaining stemness of gastric cancer stem cells by enhancing the expression of anti-apoptosis genes, ref. 131 demonstrated suppression of apoptosis via NME2-mediated miR-100 upregulation in the development of gastric cancer, and ref. 132 demonstrated that overexpression of NME2 is associated with acquired resistance to 5-fluorouracil in colorectal cancer, yet its role (alongside partnership with MYC) in Enzalutamide resistance in CRPC patients has not been explored yet. The gene discussed is NME2; the disease is gastric cancer.