First, we evaluated the enrichment of transcriptomic markers of PCa aggressiveness73–86 (n = 13, Fig. 6a) in high NME2 and MYC group, out of which ERG, and DLX1 showed significant differential expression in the high-MYC and high-NME2 group, compared to the rest of the patients, “others” (two-tailed Welch t-test p value < 0.05, Supplementary Data 7A, see Methods). Here, MYC is linked to posterior cortical atrophy.