MYC and posterior cortical atrophy: Since MYC (i.e., c-MYC) has been known to play a central role in PCa development and metastasis3,22–28, is overexpressed in 60% of CRPC patients27,29, has been shown to be associated with general ARSI response27, and could potentially be therapeutically targeted30,31, we sought to investigate MYC mechanisms for their role in response to Enzalutamide.