Among genomic markers21,32,90–92 of PCa aggressiveness (n = 12, Fig. 6b, where TP53 and RB1 have also been shown to be markers of response to ARSIs33), RB1 with shallow and deep deletion was significantly enriched in patients with high-NME2 and high-MYC pathway activity (Fisher’s exact test p value = 0.03) (Fig. 6b, Supplementary Data 7B, see Methods). This evidence concerns the gene RB1 and posterior cortical atrophy.