To work as a transcription regulator, MYC interacts with another helix-loop-helix/ leucine-zipper protein, MAX, through the C-terminal BR/HLH/LZ motif to form a complex that binds to the conserved sequences (CACGTG) in the transcriptional regulatory regions of the target genes118–120, known to be involved in proliferation121, differentiation122, cell cycle121,122, metabolism123, apoptosis121, angiogenesis124, and therapeutic resistance23,27 across different cancers. This evidence concerns the gene MAX and cancer.