PKD1 and autosomal dominant polycystic kidney disease: To determine whether common Aurka-dependent drivers of cystogenesis were apparent in our JS and ADPKD models, we compared changes in KEGG pathways in single mutants (Inpp5e or Pkd1, versus cre controls) and double mutants (Inpp5e; Aurka or Pkd1; Aurka versus single mutants) (Fig. 4c, Supplementary Data 2).