In contrast to early onset PKD induced by Hoxb7-cre mediated Pkd1 deletion (see Fig. 1k–m), cyst development was also attenuated by deletion of a single copy of Aurka. It was noted this phenomenon was less evident in proximal tubules, which may relate to differences in AURKA expression between tubule types (Fig. S3c–e). The gene discussed is AURKA; the disease is cyst.