To examine whether Aurka deletion could also ameliorate cyst development after this shift in adult mice (more analogous to ADPKD in humans), we employed a doxycycline-inducible model of ADPKD17 which employs Pax8-rtTA and TetO-Cre transgenes to mediate gene knockout in the collecting duct, proximal and distal tubules of the nephron. This evidence concerns the gene PAX8 and autosomal dominant polycystic kidney disease.