In contrast, Inpp5eΔ/Δ;AurkaΔ/Δ Alisertib-treated mice displayed no change in kidney-to-body-weight ratio, cyst index, cyst number or cyst size (Fig. 6b–e), confirming Alisertib requires AURKA (and not AURKB or other targets) to elicit these pro-cystogenic effects. Here, AURKB is linked to cyst.