Here, we show that Aurka deletion significantly and stably prevents cyst formation and/or reduces cyst size caused by loss of Pkd1. Moreover, we show that Aurka deletion also prevents the development of PKD following loss of Inpp5e. While we see slight differences in the magnitude of rescue between these models, closer examination suggests this is a technical limitation due to differing Cre efficiency across the Pkd1, Inpp5e and Aurka floxed loci. This evidence concerns the gene AURKA and cyst.