HOXB7 and cyst: In contrast to early onset PKD induced by Hoxb7-cre mediated Pkd1 deletion (see Fig. 1k–m), cyst development was also attenuated by deletion of a single copy of Aurka. It was noted this phenomenon was less evident in proximal tubules, which may relate to differences in AURKA expression between tubule types (Fig. S3c–e).