The reduction in disease severity in treated ADPKD animals was associated with corrections in the levels of cell ciliation (Fig. 7n) and a reduction in the number of collecting duct cells co-expressing AURKA, pAKT (T308) (Fig. 7o, p) and Ki67 (Fig. 7q, r). This evidence concerns the gene AURKA and autosomal dominant polycystic kidney disease.