SERPINA3 and SERPINC1 specifically have also been associated specifically with amyloidotic disorders: both are increased in CSF in early-stage AD, and SERPINA3 has been confirmed to be a major component of senile plaques and to be involved in defibrillation of amyloid in CAA and AD [56, 57]. This evidence concerns the gene SERPINC1 and Senile plaques.