HFE and Rare hereditary hemochromatosis: A recent systematic review found limited evidence linking iron intake and dementia.21 Yet, we recently reported that the iron overload disease hereditary haemochromatosis is associated with an increased risk of dementia in male homozygotes carriers of the p.C282Y mutation in the HFE gene.4 We extend our previous findings and show that genetically determined TSAT in the general population is also associated with dementia genetic liability.