In time-to-event analysis (competing risks regression) of the TSAT polygenic score on risk of clinically defined non-AD dementia, the association was independent of APOE ε4 (without adjustment subdistribution HR (sHR) 1.59; 95% CI 1.23 to 2.05, p=0.0003; with adjustment for APOE ε4 sHR 1.74; 95% CI 1.33 to 2.28, p=0.00006, all sHRs per SD in TSAT polygenic score). This evidence concerns the gene APOE and dementia.