NEDD8 and neoplasm: Primarily effective against various solid tumors such as those of the colon and lung as exhibited in preclinical studies, pevonedistat’s potent anti-tumor activity extends across multiple tumor types [199–203], and it has been proven efficacious in tumor xenograft mouse models, where it curtails tumor growth through the inhibition of NEDD8 conjugation and increasing NAE inhibition following both single and repeated doses [204].