Since that the Ubiquitin-proteasome and autophagy-lysosome pathways are two main intracellular protein degradation manners within the eukaryotic cells, we treated NPC cells with the proteasome inhibitor MG132 or lysosome inhibitor chloroquine (CQ) after transfecting with HA-NEURL3 plasmid or empty vector. This evidence concerns the gene NEURL3 and nasopharyngeal carcinoma.