To validate whether NEURL3 inhibits NPC cell migration, invasion, and EMT through promoting Vimentin degradation, we co-transfected NPC cells with NEURL3-overexpressing, Vimentin-overexpressing, or empty vector plasmids (Supplementary Fig. 6a), and then did in vitro functional experiments. Here, NEURL3 is linked to nasopharyngeal carcinoma.