In bulk RNA-seq data from a large cohort of well-characterized benign, locally advanced PCa, CRPC, and NEPC samples (https://shinyproxy.eipm-research.org/app/single-gene-expression), POSTN expression is significantly increased in a subset of CRPC and most NEPC patients compared to PCa and benign samples (Supplementary Fig. 5a). This evidence concerns the gene POSTN and posterior cortical atrophy.