This reciprocal expression is found in all mouse models of advanced adenocarcinoma and NEPC including PRN (Fig. 5c), PBCre4;Ptenf/f;Rb1f/f(DKO) and PBcre4;Ptenf/f;Rb1f/f;Trp53f/f(TKO) models33 (Supplementary Fig. 4), as well as in human samples (Fig. 5d). The gene discussed is CIAO3; the disease is adenocarcinoma.