The Nkx3.1creERT2;Ptenf/f (NP) mice12–15, and the Tg(ARR2/Pbsn-MYC)7Key (Hi-MYC) GEMMs16 represent prostatic intraepithelial neoplasia (PIN) with subsequent invasion. This evidence concerns the gene ARRB2 and prostate intraepithelial neoplasia.