SIAH1 and neoplasm: Comparing non-metastatic tumor cluster 1 versus either cluster 12 or 14, we not only found lower expression of TNFSF9 (encoding 41BBL) but also higher levels of SIAH1 which is an E3 ligase that was found to be downregulated during TGFB-induced EMT [29] (Supplementary Fig. 3B).