To investigate the role of P2RX7 in epilepsy, GSE133553 (including 6 hippocampus samples from epileptic mice and 5 samples from control mice) and GSE88992 (including 8 epileptic mouse hippocampus samples and 9 control mouse hippocampus samples) from the GEO database were selected for analysis. This evidence concerns the gene P2RX7 and epilepsy.