P2RX7 and epilepsy: To demonstrate the impact of P2RX7-knockdown on the progression of epilepsy in vivo, a P2RX7 recombinant adeno-associated virus (P2RX7-AAV) targeting neuron-specific expression was injected into the hippocampus, and a KA-induced epilepsy model was constructed after 4 weeks (Fig. 3A).