The inhibitory effects of miR-211-5p on seizures are likely associated with its inhibitory effect on ferroptosis, as (1) activation of miR-211-5p or knockdown of P2RX7 increases the GPX4 expression level and the SOD and GSH concentrations but decreases the HO-1 expression level and MDA concentration and mitochondrial membrane density, and (2) activation of miR-211-5p or knockdown of P2RX7, both of which suppress the ERK cascade in murine models of epilepsy and are closely associated with the pathogenesis of ferroptosis and oxidative stress, also alleviates seizures. Here, HMOX1 is linked to epilepsy.