GPX4 and epilepsy: The inhibitory effects of miR-211-5p on seizures are likely associated with its inhibitory effect on ferroptosis, as (1) activation of miR-211-5p or knockdown of P2RX7 increases the GPX4 expression level and the SOD and GSH concentrations but decreases the HO-1 expression level and MDA concentration and mitochondrial membrane density, and (2) activation of miR-211-5p or knockdown of P2RX7, both of which suppress the ERK cascade in murine models of epilepsy and are closely associated with the pathogenesis of ferroptosis and oxidative stress, also alleviates seizures.