We investigated the distinctive phenotype of these MITF−/low melanoma cells unveiling the loss of E-cadherin (CDH1) accompanied by concomitant increased expression of N-cadherin (CDH2) (Fig. 5), a feature associated with epithelial-to-mesenchymal transition (EMT) in various cancers including melanoma [63]. The gene discussed is CDH2; the disease is cancer.