Emerging cancer-associated pathways included the biosynthesis of nucleotides, peptides, and phospholipids and insulin signaling, along with down-regulation of the oxidative phosphorylation and monocarboxylic acid biosynthesis (Additional files 4 and 5), consistent with a cancer cell profile, as also indicated by a recent pan-cancer proteomic analysis [68]. The gene discussed is INS; the disease is cancer.