NDRG1 and neoplasm: Moreover, we observed a strong signal for phosphorylation of N-Myc downstream-regulated gene 1 (NDRG1), a distal effector of mTORC2 activation [70], in SN-MM2, SN-MM3 and SN-MM4 lines (Fig. 8A, B) as well as on SN-MM2 and SN-MM4 corresponding parental tumor biopsies (Fig. 8B), suggesting positive selection of pNDRG1+ tumor cells in vitro.